# Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)

> **NCT05312385** · PHASE3 · COMPLETED · sponsor: **Sedana Medical** · enrollment: 277 (actual)

## Conditions studied

- Sedation

## Interventions

- **DRUG:** Isoflurane
- **DRUG:** Propofol
- **DRUG:** Isoflurane (run-ins)

## Key facts

- **NCT ID:** NCT05312385
- **Lead sponsor:** Sedana Medical
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-04-28
- **Primary completion:** 2024-04-26
- **Final completion:** 2024-10-24
- **Target enrollment:** 277 (ACTUAL)
- **Last updated:** 2026-03-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05312385

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05312385, "Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT05312385. Licensed CC0.

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