# Topical Vaginal Estrogen for Postpartum Obstetric Anal Sphincter Injury Recovery

> **NCT05317364** · PHASE4 · TERMINATED · sponsor: **University of Alabama at Birmingham** · enrollment: 38 (actual)

## Conditions studied

- Obstetric; Injury Pelvic Floor
- Sexual Dysfunction
- Anal Incontinence
- Urinary Incontinence

## Interventions

- **DRUG:** Estradiol 0.01% Vag Cream
- **DRUG:** Placebo vaginal cream

## Key facts

- **NCT ID:** NCT05317364
- **Lead sponsor:** University of Alabama at Birmingham
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2022-07-14
- **Primary completion:** 2026-02-13
- **Final completion:** 2026-02-13
- **Target enrollment:** 38 (ACTUAL)
- **Why stopped:** Ran out of funding
- **Last updated:** 2026-02-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05317364

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05317364, "Topical Vaginal Estrogen for Postpartum Obstetric Anal Sphincter Injury Recovery". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT05317364. Licensed CC0.

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