# A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

> **NCT05329766** · PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **Arcus Biosciences, Inc.** · enrollment: 332 (actual)

## Conditions studied

- Gastrointestinal Tract Malignancies

## Interventions

- **DRUG:** Domvanalimab
- **DRUG:** Quemliclustat
- **DRUG:** Zimberelimab
- **DRUG:** Fluorouracil
- **DRUG:** Leucovorin
- **DRUG:** Oxaliplatin

## Key facts

- **NCT ID:** NCT05329766
- **Lead sponsor:** Arcus Biosciences, Inc.
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-06-10
- **Primary completion:** 2027-01
- **Final completion:** 2027-06
- **Target enrollment:** 332 (ACTUAL)
- **Last updated:** 2026-04-29

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05329766

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05329766, "A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies". Retrieved via AI Analytics 2026-07-28 from https://api.ai-analytics.org/clinical/NCT05329766. Licensed CC0.

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