# COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events

> **NCT05333068** · NA · ACTIVE_NOT_RECRUITING · sponsor: **Diagram B.V.** · enrollment: 1222 (estimated)

## Conditions studied

- Multivessel Coronary Artery Disease
- Ischemia
- Vulnerable Plaque
- Coronary Artery Disease

## Interventions

- **PROCEDURE:** PCI revascularization strategy based on combined FFR and OCT assessment
- **PROCEDURE:** PCI revascularization strategy based FFR assessment

## Key facts

- **NCT ID:** NCT05333068
- **Lead sponsor:** Diagram B.V.
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-03-16
- **Primary completion:** 2026-03-16
- **Final completion:** 2026-12-31
- **Target enrollment:** 1222 (ESTIMATED)
- **Last updated:** 2025-02-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05333068

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05333068, "COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05333068. Licensed CC0.

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