# IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma

> **NCT05353530** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **University of Florida** · enrollment: 39 (estimated)

## Conditions studied

- Glioblastoma Multiforme
- Glioblastoma

## Interventions

- **BIOLOGICAL:** Ex-Vivo expanded autologous IL-8 receptor (CXCR2) modified CD70 CAR (8R-70CAR) T cells

## Key facts

- **NCT ID:** NCT05353530
- **Lead sponsor:** University of Florida
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-07-25
- **Primary completion:** 2027-12
- **Final completion:** 2042-12
- **Target enrollment:** 39 (ESTIMATED)
- **Last updated:** 2026-03-09

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05353530

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05353530, "IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT05353530. Licensed CC0.

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