NKTR-255 in Combination With CAR-T Cell Therapy for the Treatment of Relapsed or Refractory Large B-cell Lymphoma
ACTIVE_NOT_RECRUITING
Status
Conditions
- Recurrent Diffuse Large B-Cell Lymphoma
- Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Recurrent Grade 3b Follicular Lymphoma
- Recurrent Primary Mediastinal Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma
- Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Refractory Grade 3b Follicular Lymphoma
- Refractory Primary Mediastinal Large B-Cell Lymphoma
- Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma
Interventions
- DRUG: Cyclophosphamide
- DRUG: Fludarabine
- BIOLOGICAL: Lisocabtagene Maraleucel
- DRUG: Polymer-conjugated IL-15 Receptor Agonist NKTR-255
- PROCEDURE: X-Ray Imaging
- PROCEDURE: Echocardiography
- PROCEDURE: Multigated Acquisition Scan
- PROCEDURE: Bone Marrow Biopsy
- PROCEDURE: Bone Marrow Aspiration
- PROCEDURE: Lumbar Puncture
- PROCEDURE: Computed Tomography
- PROCEDURE: Positron Emission Tomography
- PROCEDURE: Biospecimen Collection
- PROCEDURE: Biopsy
Sponsor
Fred Hutchinson Cancer Center
Collaborators