# Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation

> **NCT05360030** · NA · COMPLETED · sponsor: **Second Affiliated Hospital, School of Medicine, Zhejiang University** · enrollment: 45 (actual)

## Conditions studied

- Chronic Pain
- rTMS

## Interventions

- **DRUG:** Naloxone
- **DRUG:** Saline
- **DRUG:** Ketamine Hydrochloride
- **DEVICE:** pcTBS of M1
- **DEVICE:** pcTBS of DLPFC
- **DEVICE:** SHAM stimulation

## Key facts

- **NCT ID:** NCT05360030
- **Lead sponsor:** Second Affiliated Hospital, School of Medicine, Zhejiang University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-05-14
- **Primary completion:** 2022-12-01
- **Final completion:** 2022-12-31
- **Target enrollment:** 45 (ACTUAL)
- **Last updated:** 2023-02-16


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05360030

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05360030, "Mechanism of Analgesic Effect on Prolonged Continuous Theta Burst Stimulation". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05360030. Licensed CC0.

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