Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

NCT05372614 · clinicaltrials.gov ↗

PHASE1

Phase

SUSPENDED

Status

33

Enrollment

NIH

Sponsor class

Stopped Other - Correlative sample analysis.

Conditions

Metastatic Malignant Solid Neoplasm
Unresectable Malignant Solid Neoplasm

Interventions

PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
PROCEDURE: Multigated Acquisition Scan
DRUG: Neratinib Maleate
BIOLOGICAL: Trastuzumab Deruxtecan

Sponsor

National Cancer Institute (NCI)