# A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

> **NCT05382338** · PHASE3 · RECRUITING · sponsor: **Children's Oncology Group** · enrollment: 225 (estimated)

## Conditions studied

- Childhood Medulloblastoma

## Interventions

- **PROCEDURE:** Audiometric Test
- **PROCEDURE:** Auditory Brainstem Response
- **PROCEDURE:** Biospecimen Collection
- **DRUG:** Cisplatin
- **DRUG:** Cyclophosphamide
- **DRUG:** Lomustine
- **PROCEDURE:** Magnetic Resonance Imaging
- **OTHER:** Quality-of-Life Assessment
- **RADIATION:** Radiation Therapy
- **DRUG:** Sodium Thiosulfate
- **OTHER:** Survey Administration
- **DRUG:** Vincristine

## Key facts

- **NCT ID:** NCT05382338
- **Lead sponsor:** Children's Oncology Group
- **Sponsor class:** NETWORK
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-02-20
- **Primary completion:** 2029-12-31
- **Final completion:** 2029-12-31
- **Target enrollment:** 225 (ESTIMATED)
- **Last updated:** 2026-05-05

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05382338

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05382338, "A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT05382338. Licensed CC0.

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