# A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive Disorder

> **NCT05385783** · PHASE1,PHASE2 · COMPLETED · sponsor: **Cybin IRL Limited** · enrollment: 57 (actual)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DRUG:** CYB003
- **BEHAVIORAL:** Psychotherapy
- **DRUG:** Placebo
- **BEHAVIORAL:** Psychological Support

## Key facts

- **NCT ID:** NCT05385783
- **Lead sponsor:** Cybin IRL Limited
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-08-02
- **Primary completion:** 2023-10-16
- **Final completion:** 2024-01-18
- **Target enrollment:** 57 (ACTUAL)
- **Last updated:** 2024-03-25

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05385783

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05385783, "A Study of a Psilocybin Analog (CYB003) in Healthy Participants With and Without Major Depressive Disorder". Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/clinical/NCT05385783. Licensed CC0.

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