# PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years

> **NCT05387954** · PHASE3 · RECRUITING · sponsor: **Assistance Publique - Hôpitaux de Paris** · enrollment: 792 (estimated)

## Conditions studied

- Cryptogenic Ischemic Stroke
- Patent Foramen Ovale

## Interventions

- **PROCEDURE:** Transcatheter PFO closure
- **DRUG:** Oral Anticoagulant, Direct-Acting
- **DRUG:** Antiplatelet therapy

## Key facts

- **NCT ID:** NCT05387954
- **Lead sponsor:** Assistance Publique - Hôpitaux de Paris
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-07-07
- **Primary completion:** 2031-07-07
- **Final completion:** 2031-07-07
- **Target enrollment:** 792 (ESTIMATED)
- **Last updated:** 2026-03-24

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05387954

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05387954, "PFO Closure, Oral Anticoagulants or Antiplatelet Therapy After PFO-associated Stroke in Patients Aged 60 to 80 Years". Retrieved via AI Analytics 2026-07-13 from https://api.ai-analytics.org/clinical/NCT05387954. Licensed CC0.

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