# Estrogen Variability and Irritability During the Menopause Transition

> **NCT05388656** · PHASE4 · COMPLETED · sponsor: **University of North Carolina, Chapel Hill** · enrollment: 40 (actual)

## Conditions studied

- Menopause
- Irritable Mood

## Interventions

- **DRUG:** Estradiol Patch, 0.1 mg/24 Hours Weekly Transdermal Film, Extended Release
- **DRUG:** Placebo
- **DRUG:** Progesterone 200 mg

## Key facts

- **NCT ID:** NCT05388656
- **Lead sponsor:** University of North Carolina, Chapel Hill
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-06-15
- **Primary completion:** 2024-12-17
- **Final completion:** 2025-01-17
- **Target enrollment:** 40 (ACTUAL)
- **Last updated:** 2025-11-26

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05388656

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05388656, "Estrogen Variability and Irritability During the Menopause Transition". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT05388656. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*