# Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

> **NCT05388773** · PHASE2 · RECRUITING · sponsor: **Heath Skinner** · enrollment: 150 (estimated)

## Conditions studied

- Oropharynx Cancer

## Interventions

- **PROCEDURE:** therapeutic conventional surgery
- **OTHER:** laboratory biomarker analysis
- **OTHER:** quality-of-life assessment
- **RADIATION:** intensity-modulated radiation therapy
- **DRUG:** Cisplatin
- **DRUG:** Carboplatin

## Key facts

- **NCT ID:** NCT05388773
- **Lead sponsor:** Heath Skinner
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-07-20
- **Primary completion:** 2028-12-31
- **Final completion:** 2030-12-31
- **Target enrollment:** 150 (ESTIMATED)
- **Last updated:** 2025-06-19


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05388773

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05388773, "Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT05388773. Licensed CC0.

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