# The BEST Trial: Biomarkers for Evaluating Spine Treatments

> **NCT05396014** · PHASE4 · COMPLETED · sponsor: **University of North Carolina, Chapel Hill** · enrollment: 1014 (actual)

## Conditions studied

- Chronic Low-back Pain

## Interventions

- **BEHAVIORAL:** Enhanced Self-Care (ESC)
- **BEHAVIORAL:** Acceptance and Commitment Therapy (ACT)
- **BEHAVIORAL:** Evidence-Based Exercise and Manual Therapy (EBEM)
- **DRUG:** Duloxetine

## Key facts

- **NCT ID:** NCT05396014
- **Lead sponsor:** University of North Carolina, Chapel Hill
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-09-12
- **Primary completion:** 2024-07-30
- **Final completion:** 2024-10-22
- **Target enrollment:** 1014 (ACTUAL)
- **Last updated:** 2025-07-23

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05396014

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05396014, "The BEST Trial: Biomarkers for Evaluating Spine Treatments". Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/clinical/NCT05396014. Licensed CC0.

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