# SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer

> **NCT05412082** · PHASE1 · RECRUITING · sponsor: **University of Miami** · enrollment: 25 (estimated)

## Conditions studied

- Locally Advanced Rectal Cancer

## Interventions

- **RADIATION:** Intensity-modulated radiation therapy
- **DRUG:** 5-fluorouracil
- **DRUG:** Leucovorin
- **DRUG:** Oxaliplatin
- **DRUG:** Capecitabine
- **RADIATION:** Accelerated Radiation Therapy
- **DRUG:** Irinotecan

## Key facts

- **NCT ID:** NCT05412082
- **Lead sponsor:** University of Miami
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-10-05
- **Primary completion:** 2026-10-31
- **Final completion:** 2028-10-31
- **Target enrollment:** 25 (ESTIMATED)
- **Last updated:** 2026-02-06


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05412082

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05412082, "SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer". Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/clinical/NCT05412082. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*