# Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis

> **NCT05413304** · PHASE1 · ACTIVE_NOT_RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 1 (actual)

## Conditions studied

- Glioma

## Interventions

- **DRUG:** pre-operative abemaciclib
- **DEVICE:** Device for Cerebral Fluid Dialysate Collection
- **DEVICE:** Ashion Analytics GEM ExTra
- **DRUG:** abemaciclib + temozolomide

## Key facts

- **NCT ID:** NCT05413304
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-04-07
- **Primary completion:** 2025-10-21
- **Final completion:** 2027-09-01
- **Target enrollment:** 1 (ACTUAL)
- **Last updated:** 2026-03-24


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05413304

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05413304, "Abemaciclib Neuropharmacokinetics of Diffuse Midline Glioma Using Intratumoral Microdialysis". Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/clinical/NCT05413304. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*