# An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results

> **NCT05420064** · NA · RECRUITING · sponsor: **Memorial Sloan Kettering Cancer Center** · enrollment: 1000 (estimated)

## Conditions studied

- BRCA1 Mutation
- POLD1 Gene Mutation
- CDKN2A Mutation
- BRCA2 Mutation
- POLE Gene Mutation
- APC Gene Mutation
- ATM Gene Mutation
- MLH1 Gene Mutation
- BARD1 Gene Mutation
- MSH2 Gene Mutation
- BRIP1 Gene Mutation
- MSH6 Gene Mutation
- CHEK2 Gene Mutation
- PMS2 Gene Mutation
- PALB2 Gene Mutation
- EPCAM Gene Mutation
- RAD51C Gene Mutation
- BMPR1A Gene Mutation
- RAD51D Gene Mutation
- SMAD4
- PTEN Gene Mutation
- GREM1

## Interventions

- **BEHAVIORAL:** Intervention Arm At-risk Relative/ARR Contacts
- **BEHAVIORAL:** MyGene Portal
- **BEHAVIORAL:** Standard of Care

## Key facts

- **NCT ID:** NCT05420064
- **Lead sponsor:** Memorial Sloan Kettering Cancer Center
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-12-01
- **Primary completion:** 2026-05-31
- **Final completion:** 2026-11-30
- **Target enrollment:** 1000 (ESTIMATED)
- **Last updated:** 2025-11-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05420064

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05420064, "An Intervention to Increase Genetic Testing in Families Who May Share a Gene Mutation Related to Cancer Risk and An Intervention to Help Patients and Their Primary Care Providers Stay Up-to-date About Uncertain Genetic Test Results". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT05420064. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*