# Platform of Randomized Adaptive Clinical Trials in Critical Illness

> **NCT05440851** · NA · RECRUITING · sponsor: **University Health Network, Toronto** · enrollment: 6250 (estimated)

## Conditions studied

- Respiratory Insufficiency
- Extracorporeal Membrane Oxygenation Complication
- Mechanical Ventilation Pressure High

## Interventions

- **OTHER:** Ultra-Protective Ventilation Facilitated by Extracorporeal Support
- **OTHER:** Lung-Protective Ventilation (LPV)
- **OTHER:** Driving Pressure-Limited Ventilation (DPL)
- **OTHER:** Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS)
- **DRUG:** Early Cohort corticosteroid dose
- **DRUG:** Extended Cohort corticosteroid dose
- **DRUG:** Usual care without routine corticosteroids
- **DRUG:** Usual care without extending corticosteroids
- **DRUG:** Usual care with fludrocortisone
- **DRUG:** Usual care without fludrocortisone
- **DRUG:** Drug 4 mL:
- **DRUG:** Drug 40 mg:
- **OTHER:** PEEP-20
- **OTHER:** PEEP-AOP
- **OTHER:** PEEP-10
- **OTHER:** VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation
- **OTHER:** Electrical impedance tomography (EIT)
- **OTHER:** no treatment / intervention arm is involved
- **OTHER:** Usual care
- **OTHER:** Early Routine IMT

## Key facts

- **NCT ID:** NCT05440851
- **Lead sponsor:** University Health Network, Toronto
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-04-30
- **Primary completion:** 2027-03-31
- **Final completion:** 2027-03-31
- **Target enrollment:** 6250 (ESTIMATED)
- **Last updated:** 2026-05-07


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05440851

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05440851, "Platform of Randomized Adaptive Clinical Trials in Critical Illness". Retrieved via AI Analytics 2026-06-30 from https://api.ai-analytics.org/clinical/NCT05440851. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*