# Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults

> **NCT05441410** · PHASE1,PHASE2 · NOT_YET_RECRUITING · sponsor: **University Hospital Tuebingen** · enrollment: 30 (estimated)

## Conditions studied

- Malaria

## Interventions

- **DRUG:** Pyronaridine Tetraphosphate, Artesunate Drug Combination
- **BIOLOGICAL:** PfSPZ Challenge (NF54)
- **BIOLOGICAL:** MVA ME-TRAP
- **BIOLOGICAL:** ChAd63 ME-TRAP
- **BIOLOGICAL:** Sodium chloride (NaCl) 0.9%

## Key facts

- **NCT ID:** NCT05441410
- **Lead sponsor:** University Hospital Tuebingen
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** NOT_YET_RECRUITING
- **Start date:** 2025-06-01
- **Primary completion:** 2026-06-30
- **Final completion:** 2026-06-30
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2024-12-06

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05441410

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05441410, "Comparing Safety and Protective Efficacy of Vaccine Candidate PfSPZ-CVac and MVA ME-TRAP/ ChAd63 ME-TRAP in Adults". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05441410. Licensed CC0.

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