# Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies

> **NCT05443425** · PHASE1 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 18 (estimated)

## Conditions studied

- Acute Graft Versus Host Disease
- Hematopoietic and Lymphoid System Neoplasm

## Interventions

- **DRUG:** Cholestyramine
- **DRUG:** Leflunomide
- **DRUG:** Steroid Therapy

## Key facts

- **NCT ID:** NCT05443425
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-06-16
- **Primary completion:** 2027-01-05
- **Final completion:** 2027-01-05
- **Target enrollment:** 18 (ESTIMATED)
- **Last updated:** 2025-07-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05443425

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05443425, "Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies". Retrieved via AI Analytics 2026-07-11 from https://api.ai-analytics.org/clinical/NCT05443425. Licensed CC0.

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