Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Conditions

• Acute Lymphoblastic Leukemia
• Acute Myeloid Leukemia
• Mixed Phenotype Acute Leukemia
• Myelodysplastic Syndrome

Interventions

• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspiration
• DRUG: Busulfan
• DRUG: Cyclophosphamide
• PROCEDURE: Echocardiography Test
• DRUG: Fludarabine
• PROCEDURE: Haploidentical Hematopoietic Cell Transplantation
• BIOLOGICAL: Lapine T-Lymphocyte Immune Globulin
• PROCEDURE: Lumbar Puncture
• PROCEDURE: Matched Unrelated Donor Hematopoietic Cell Transplantation
• DRUG: Melphalan
• DRUG: Methotrexate
• PROCEDURE: Multigated Acquisition Scan
• DRUG: Mycophenolate Mofetil
• PROCEDURE: Myeloablative Conditioning
• OTHER: Quality-of-Life Assessment
• OTHER: Questionnaire Administration
• BIOLOGICAL: Rituximab
• PROCEDURE: T-Cell Depletion Therapy
• DRUG: Tacrolimus

Sponsor

Children's Oncology Group