# Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion

> **NCT05461092** · EARLY_PHASE1 · RECRUITING · sponsor: **University of Iowa** · enrollment: 50 (estimated)

## Conditions studied

- Delirium
- Pain, Back
- Spinal Fusion
- Thoracolumbar Interfascial Plane Block

## Interventions

- **DRUG:** Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine
- **DIAGNOSTIC_TEST:** Blood Test
- **OTHER:** 3D CAM Delirium Severity Scoring
- **OTHER:** Generalized Anxiety Disorder 7-item (GAD-7) scale
- **OTHER:** Numerical Rating Score (NRS)
- **OTHER:** PROMIS-Pain Interference
- **OTHER:** Oswestry Disability Index (ODI)
- **OTHER:** Saint Louis University Mental Status Examination (SLUMs)
- **OTHER:** Delirium Rating Scale-Revised-98 (DRS)
- **OTHER:** Telephone Interview for Cognitive Status - Modified (TICS-M)
- **OTHER:** Opioid Equivalents measured by Morphine Milligram Equivalents (MME)
- **OTHER:** Patient Health Questionnaire depression scale (PHQ-8)
- **OTHER:** Pain Catastrophizing
- **OTHER:** Fear Avoidance Beliefs Questionnaire (FABQ)
- **OTHER:** Opioid Side Effects and Likeability Questionnaire
- **OTHER:** Daily Pain Trajectory
- **OTHER:** Tampa Scale of Kinesiophobia
- **OTHER:** Quality of Recovery 15

## Key facts

- **NCT ID:** NCT05461092
- **Lead sponsor:** University of Iowa
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2024-01-01
- **Primary completion:** 2026-12-31
- **Final completion:** 2026-12-31
- **Target enrollment:** 50 (ESTIMATED)
- **Last updated:** 2026-03-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05461092

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05461092, "Regional Nerve Blocks to Improve Analgesia and Recovery in Older Adults Undergoing Spinal Fusion". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05461092. Licensed CC0.

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