# A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA

> **NCT05462990** · PHASE2 · TERMINATED · sponsor: **Novartis Pharmaceuticals** · enrollment: 101 (actual)

## Conditions studied

- Osteoarthritis, Knee

## Interventions

- **DRUG:** QUC398
- **DRUG:** Placebo

## Key facts

- **NCT ID:** NCT05462990
- **Lead sponsor:** Novartis Pharmaceuticals
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2022-11-09
- **Primary completion:** 2024-08-02
- **Final completion:** 2025-04-08
- **Target enrollment:** 101 (ACTUAL)
- **Why stopped:** Sponsor Decision
- **Last updated:** 2026-03-31


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05462990

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05462990, "A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT05462990. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*