# Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA

> **NCT05517434** · PHASE2,PHASE3 · RECRUITING · sponsor: **University Health Network, Toronto** · enrollment: 148 (estimated)

## Conditions studied

- Osteoarthritis, Knee

## Interventions

- **BIOLOGICAL:** Bone Marrow Aspirate (BMA): Minimally manipulated autologous cellular preparation
- **OTHER:** Saline (Placebo Comparator for BMA)
- **BIOLOGICAL:** Lipoaspirate Micronized + Leukocyte-Poor Platelet-Rich Plasma (LAM + LP-PRP): Minimally manipulated autologous cellular preparations
- **OTHER:** Saline (Placebo Comparator for LAM + LP-PRP)

## Key facts

- **NCT ID:** NCT05517434
- **Lead sponsor:** University Health Network, Toronto
- **Sponsor class:** OTHER
- **Phase:** PHASE2,PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2025-01-01
- **Primary completion:** 2026-06
- **Final completion:** 2026-12
- **Target enrollment:** 148 (ESTIMATED)
- **Last updated:** 2025-12-19

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05517434

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05517434, "Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05517434. Licensed CC0.

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