# A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)

> **NCT05518149** · PHASE3 · TERMINATED · sponsor: **Janssen Research & Development, LLC** · enrollment: 871 (actual)

## Conditions studied

- Depressive Disorder, Major

## Interventions

- **DRUG:** Aticaprant

## Key facts

- **NCT ID:** NCT05518149
- **Lead sponsor:** Janssen Research & Development, LLC
- **Sponsor class:** INDUSTRY
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** TERMINATED
- **Start date:** 2022-09-22
- **Primary completion:** 2025-04-25
- **Final completion:** 2025-05-08
- **Target enrollment:** 871 (ACTUAL)
- **Why stopped:** The study was Early Terminated as per Sponsor's decision (communicated to sites on 06Mar2025)
- **Last updated:** 2026-04-15


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05518149

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05518149, "A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD)". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05518149. Licensed CC0.

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