# Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale

> **NCT05546320** · PHASE2 · COMPLETED · sponsor: **Chinese Academy of Medical Sciences, Fuwai Hospital** · enrollment: 1000 (actual)

## Conditions studied

- Patent Foramen Ovale
- Migraine

## Interventions

- **DRUG:** Aspirin 300mg
- **DRUG:** Metoprolol 25mg
- **DRUG:** Clopidogrel 75mg
- **DRUG:** Rivaroxaban 20mg

## Key facts

- **NCT ID:** NCT05546320
- **Lead sponsor:** Chinese Academy of Medical Sciences, Fuwai Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-10-15
- **Primary completion:** 2025-03-26
- **Final completion:** 2025-03-26
- **Target enrollment:** 1000 (ACTUAL)
- **Last updated:** 2026-04-22


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05546320

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05546320, "Comparison of the Effect of Medication Therapy in Alleviating Migraine With Patent Foramen Ovale". Retrieved via AI Analytics 2026-05-28 from https://api.ai-analytics.org/clinical/NCT05546320. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*