Testing the Use of Fulvestrant and Binimetinib Targeted Treatment for NF1 Mutation in Hormone Receptor-Positive Metastatic Breast Cancer (A ComboMATCH Treatment Trial)

NCT05554354 · clinicaltrials.gov ↗

PHASE2

Phase

TERMINATED

Status

1

Enrollment

NIH

Sponsor class

Stopped Other - slow accrual

Conditions

Anatomic Stage IV Breast Cancer AJCC v8
Metastatic HER2-Negative Breast Carcinoma
Metastatic Hormone Receptor-Positive Breast Carcinoma

Interventions

DRUG: Binimetinib
PROCEDURE: Biopsy Procedure
PROCEDURE: Biospecimen Collection
PROCEDURE: Bone Scan
PROCEDURE: Computed Tomography
PROCEDURE: Echocardiography Test
DRUG: Fulvestrant
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Multigated Acquisition Scan

Sponsor

National Cancer Institute (NCI)

Collaborators

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