Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

Conditions

• Acute Myeloid Leukemia
• Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm
• Acute Myeloid Leukemia Post Cytotoxic Therapy
• Acute Myeloid Leukemia, Myelodysplasia-Related

Interventions

• DRUG: Azacitidine
• PROCEDURE: Biospecimen Collection
• PROCEDURE: Bone Marrow Aspiration
• DRUG: Cytarabine
• DRUG: Daunorubicin Hydrochloride
• PROCEDURE: Echocardiography Test
• DRUG: Liposome-encapsulated Daunorubicin-Cytarabine
• PROCEDURE: Multigated Acquisition Scan
• DRUG: Venetoclax

Sponsor

National Cancer Institute (NCI)