# GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.

> **NCT05562518** · PHASE4 · ACTIVE_NOT_RECRUITING · sponsor: **University Hospital, Ghent** · enrollment: 160 (estimated)

## Conditions studied

- Vulvovaginal Atrophy
- Breast Cancer

## Interventions

- **DRUG:** Estrogen
- **DRUG:** dehydroepiandrosterone
- **DRUG:** Estrogen + probiotics
- **DRUG:** Moisturizer

## Key facts

- **NCT ID:** NCT05562518
- **Lead sponsor:** University Hospital, Ghent
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2022-03-21
- **Primary completion:** 2026-03-02
- **Final completion:** 2027-12-31
- **Target enrollment:** 160 (ESTIMATED)
- **Last updated:** 2026-04-30

## Collaborators

- University Ghent

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05562518

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05562518, "GRACE-trial: a Randomized Active-controlled Trial for vulvovaGinal atRophy in breAst Cancer Patients on Endocrine Therapy.". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05562518. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*