# Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

> **NCT05564377** · PHASE2 · RECRUITING · sponsor: **National Cancer Institute (NCI)** · enrollment: 2900 (estimated)

## Conditions studied

- Advanced Malignant Solid Neoplasm
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage IV Breast Cancer AJCC v8
- Locally Advanced Malignant Solid Neoplasm
- Malignant Female Reproductive System Neoplasm
- Metastatic HER2-Negative Breast Carcinoma
- Metastatic Malignant Solid Neoplasm
- Recurrent Endometrial Carcinoma
- Recurrent Fallopian Tube Carcinoma
- Recurrent Malignant Female Reproductive System Neoplasm
- Recurrent Malignant Solid Neoplasm
- Recurrent Ovarian Carcinoma
- Recurrent Primary Peritoneal Carcinoma
- Unresectable HER2-Negative Breast Carcinoma
- Unresectable Malignant Solid Neoplasm

## Interventions

- **DRUG:** Alpelisib
- **DRUG:** Binimetinib
- **PROCEDURE:** Biopsy Procedure
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Bone Marrow Aspiration
- **PROCEDURE:** Bone Marrow Biopsy
- **PROCEDURE:** Bone Scan
- **PROCEDURE:** Computed Tomography
- **PROCEDURE:** Echocardiography Test
- **DRUG:** Fluorouracil
- **DRUG:** Fulvestrant
- **DRUG:** Ipatasertib
- **DRUG:** Leucovorin
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Multigated Acquisition Scan
- **PROCEDURE:** Mutation Carrier Screening
- **DRUG:** Neratinib Maleate
- **DRUG:** Nilotinib Hydrochloride Monohydrate
- **DRUG:** Olaparib
- **DRUG:** Oxaliplatin

## Key facts

- **NCT ID:** NCT05564377
- **Lead sponsor:** National Cancer Institute (NCI)
- **Sponsor class:** NIH
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-04-07
- **Primary completion:** 2030-07-01
- **Final completion:** 2030-07-01
- **Target enrollment:** 2900 (ESTIMATED)
- **Last updated:** 2026-05-18


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05564377

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05564377, "Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial". Retrieved via AI Analytics 2026-08-03 from https://api.ai-analytics.org/clinical/NCT05564377. Licensed CC0.

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