Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease

Stopped The study was stopped before enrollment, after a feasibility review revealed we would be unable to measure the primary endpoint (flow mediated dilation - FMD) with a high degree of reproducibility and minimum variability in a multi-country setting.

Conditions

• Cardiovascular Diseases
• Smoking
• Tobacco Use
• Peripheral Arterial Disease
• Coronary Artery Disease

Interventions

• OTHER: Cigarette
• OTHER: THS
• OTHER: Smoking Abstinence

Sponsor

Philip Morris Products S.A.