# Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

> **NCT05570812** · PHASE2 · RECRUITING · sponsor: **Massachusetts General Hospital** · enrollment: 120 (estimated)

## Conditions studied

- Major Depressive Disorder
- Anxiety Depression
- HIV

## Interventions

- **DRUG:** Placebo
- **DRUG:** Pregnenolone

## Key facts

- **NCT ID:** NCT05570812
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-03-03
- **Primary completion:** 2027-06-30
- **Final completion:** 2028-01-31
- **Target enrollment:** 120 (ESTIMATED)
- **Last updated:** 2025-09-12

## Collaborators

- [object Object]
- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05570812

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05570812, "Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV". Retrieved via AI Analytics 2026-06-04 from https://api.ai-analytics.org/clinical/NCT05570812. Licensed CC0.

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