# SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer

> **NCT05576480** · PHASE2 · RECRUITING · sponsor: **Ruijin Hospital** · enrollment: 55 (estimated)

## Conditions studied

- Rectal Cancer
- Locally Advanced

## Interventions

- **RADIATION:** Short-course radiotherapy
- **DRUG:** Penpulimab
- **DRUG:** CAPEOX
- **PROCEDURE:** TME surgery

## Key facts

- **NCT ID:** NCT05576480
- **Lead sponsor:** Ruijin Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-02-06
- **Primary completion:** 2025-10
- **Final completion:** 2026-12
- **Target enrollment:** 55 (ESTIMATED)
- **Last updated:** 2025-08-28

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05576480

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05576480, "SCRT Sequential Penpulimab in Combination With CAPEOX in the Neoadjuvant Treatment of MSS Locally Advanced Rectal Cancer". Retrieved via AI Analytics 2026-07-04 from https://api.ai-analytics.org/clinical/NCT05576480. Licensed CC0.

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