# PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial

> **NCT05585411** · NA · RECRUITING · sponsor: **Yonsei University** · enrollment: 450 (estimated)

## Conditions studied

- Bradyarrhythmia
- Atrioventricular Block
- Left Bundle Branch Area Pacing

## Interventions

- **PROCEDURE:** Left bundle branch area pacing
- **PROCEDURE:** Right ventricular pacing

## Key facts

- **NCT ID:** NCT05585411
- **Lead sponsor:** Yonsei University
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-11-01
- **Primary completion:** 2026-11-01
- **Final completion:** 2026-11-01
- **Target enrollment:** 450 (ESTIMATED)
- **Last updated:** 2026-01-05


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05585411

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05585411, "PReventive Effect Of Left Bundle Branch Area Pacing Versus righT vEntricular paCing on All Cause deaTh, Heart Failure Progression, and Ventricular dysSYNChrony in Patients With Substantial Ventricular Pacing (PROTECT-SYNC): Multicenter Prospective Randomized Controlled Trial". Retrieved via AI Analytics 2026-07-20 from https://api.ai-analytics.org/clinical/NCT05585411. Licensed CC0.

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