# A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)

> **NCT05600426** · PHASE3 · ACTIVE_NOT_RECRUITING · sponsor: **Boston Children's Hospital** · enrollment: 53 (actual)

## Conditions studied

- Severe Aplastic Anemia

## Interventions

- **DRUG:** cyclosporine
- **PROCEDURE:** Matched Unrelated Donor Hematopoetic Stem Cell Transplant
- **DRUG:** horse anti-thymocyte globulin (ATG)
- **DRUG:** rabbit anti-thymocyte globulin (ATG)
- **DRUG:** Methotrexate
- **DRUG:** Fludarabine
- **DRUG:** Cyclophosphamide
- **RADIATION:** low-dose total body irradiation (TBI)
- **PROCEDURE:** Immunosuppressive Therapy (IST)

## Key facts

- **NCT ID:** NCT05600426
- **Lead sponsor:** Boston Children's Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE3
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-01-25
- **Primary completion:** 2029-12
- **Final completion:** 2029-12
- **Target enrollment:** 53 (ACTUAL)
- **Last updated:** 2026-02-17

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05600426

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05600426, "A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Anemia (TransIT, BMT CTN 2202)". Retrieved via AI Analytics 2026-06-12 from https://api.ai-analytics.org/clinical/NCT05600426. Licensed CC0.

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