Testing the Addition of an Anti-Cancer Drug, Irinotecan, to the Standard Chemotherapy Treatment (FOLFOX) After Long-Course Radiation Therapy for Advanced-Stage Rectal Cancers to Improve the Rate of Complete Response and Long-Term Rates of Organ Preservation

NCT05610163 · clinicaltrials.gov ↗

PHASE2

Phase

ACTIVE_NOT_RECRUITING

Status

783

Enrollment

OTHER

Sponsor class

Conditions

Locally Advanced Rectal Carcinoma
Stage II Rectal Cancer AJCC v8
Stage III Rectal Cancer AJCC v8

Interventions

DRUG: Capecitabine
DRUG: 5-fluorouracil
DRUG: Leucovorin calcium
DRUG: Irinotecan
DRUG: Oxaliplatin
RADIATION: Long Course Chemoradiotherapy
PROCEDURE: Computed Tomography
PROCEDURE: Magnetic Resonance Imaging
PROCEDURE: Sigmoidoscopy
PROCEDURE: biopsy

Sponsor

Alliance for Clinical Trials in Oncology

Collaborators

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