# Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression

> **NCT05615948** · PHASE4 · COMPLETED · sponsor: **Theresa Jacob, PhD, MPH** · enrollment: 15 (actual)

## Conditions studied

- Treatment Resistant Depression
- Major Depressive Disorder
- Analgesia
- Ketamine
- Peripheral Nervous System Agents
- Central Nervous System Depressants
- Neurotransmitter Agents
- Anti-Inflammatory Agents
- Physiological Effects of Drugs
- Sensory System Agents
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents, Non-Steroidal
- Depressive Symptoms

## Interventions

- **DRUG:** VTS-K

## Key facts

- **NCT ID:** NCT05615948
- **Lead sponsor:** Theresa Jacob, PhD, MPH
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-12-06
- **Primary completion:** 2024-05-17
- **Final completion:** 2024-05-17
- **Target enrollment:** 15 (ACTUAL)
- **Last updated:** 2026-04-21


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05615948

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05615948, "Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression". Retrieved via AI Analytics 2026-06-24 from https://api.ai-analytics.org/clinical/NCT05615948. Licensed CC0.

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