# Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma

> **NCT05625594** · PHASE1 · RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 20 (estimated)

## Conditions studied

- Central Nervous System Lymphoma

## Interventions

- **PROCEDURE:** Aspiration
- **PROCEDURE:** Biospecimen Collection
- **PROCEDURE:** Catheterization
- **BIOLOGICAL:** CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem T-lymphocytes
- **PROCEDURE:** Computed Tomography
- **DRUG:** Cyclophosphamide
- **DRUG:** Fludarabine
- **PROCEDURE:** Leukapheresis
- **PROCEDURE:** Lumbar Puncture
- **PROCEDURE:** Magnetic Resonance Imaging
- **PROCEDURE:** Positron Emission Tomography

## Key facts

- **NCT ID:** NCT05625594
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-06-29
- **Primary completion:** 2026-05-21
- **Final completion:** 2026-05-21
- **Target enrollment:** 20 (ESTIMATED)
- **Last updated:** 2025-07-08

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05625594

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05625594, "Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT05625594. Licensed CC0.

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