# Orexin s Role in the Neurobiology of Substance Use Disorder

> **NCT05630781** · NA · RECRUITING · sponsor: **National Institute on Drug Abuse (NIDA)** · enrollment: 140 (estimated)

## Conditions studied

- Nicotine Dependence

## Interventions

- **DRUG:** Belsomra
- **DRUG:** Placebo
- **DRUG:** Methylphenidate

## Key facts

- **NCT ID:** NCT05630781
- **Lead sponsor:** National Institute on Drug Abuse (NIDA)
- **Sponsor class:** NIH
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-02-15
- **Primary completion:** 2027-12-31
- **Final completion:** 2027-12-31
- **Target enrollment:** 140 (ESTIMATED)
- **Last updated:** 2026-04-13


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05630781

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05630781, "Orexin s Role in the Neurobiology of Substance Use Disorder". Retrieved via AI Analytics 2026-07-07 from https://api.ai-analytics.org/clinical/NCT05630781. Licensed CC0.

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