# Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression

> **NCT05630963** · — · RECRUITING · sponsor: **Mclean Hospital** · enrollment: 228 (estimated)

## Conditions studied

- Major Depressive Disorder

## Interventions

- **DEVICE:** Aversive stimuli
- **DRUG:** PET radiotracer

## Key facts

- **NCT ID:** NCT05630963
- **Lead sponsor:** Mclean Hospital
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2021-12-29
- **Primary completion:** 2026-10-28
- **Final completion:** 2027-02-28
- **Target enrollment:** 228 (ESTIMATED)
- **Last updated:** 2025-10-21

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05630963

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05630963, "Beyond Monoamines: The Role of the Nociceptin/Orphanin FQ Receptor in Major Depression". Retrieved via AI Analytics 2026-06-26 from https://api.ai-analytics.org/clinical/NCT05630963. Licensed CC0.

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*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*