# Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery

> **NCT05635227** · NA · RECRUITING · sponsor: **Rigshospitalet, Denmark** · enrollment: 1200 (estimated)

## Conditions studied

- Coronary Artery Disease
- Aortic Valve Disease

## Interventions

- **DRUG:** Dexamethasone phosphate
- **DRUG:** Isotonic sodium chloride (0.9%)
- **DRUG:** Olanzapine 10 MG
- **DRUG:** Placebo capsule
- **PROCEDURE:** Flow-targeted hemodynamic management
- **PROCEDURE:** Pressure-targeted hemodynamic management
- **PROCEDURE:** Low tidal-volume ventilation
- **PROCEDURE:** No ventilation

## Key facts

- **NCT ID:** NCT05635227
- **Lead sponsor:** Rigshospitalet, Denmark
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-11-10
- **Primary completion:** 2027-12
- **Final completion:** 2028-02
- **Target enrollment:** 1200 (ESTIMATED)
- **Last updated:** 2025-04-04


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05635227

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05635227, "Dexamethasone, Olanzapine, Hemodynamics, and Ventilation in Cardiac Surgery". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05635227. Licensed CC0.

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