# Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial

> **NCT05639712** · PHASE4 · COMPLETED · sponsor: **Oslo University Hospital** · enrollment: 1020 (actual)

## Conditions studied

- Opioid Use
- Affective Symptoms

## Interventions

- **DRUG:** Placebo
- **DRUG:** Morphine 2.5 mg i.v.
- **DRUG:** Morphine 5 mg i.v.
- **DRUG:** Morphine 10 mg i.v.
- **DRUG:** Oxycodone 2.5 mg i.v.
- **DRUG:** Oxycodone 5 mg i.v.
- **DRUG:** Oxycodone 10 mg i.v.
- **DRUG:** Fentanyl 0.025 mg i.v.
- **DRUG:** Fentanyl 0.05 mg i.v.
- **DRUG:** Fentanyl 0.1 mg i.v.

## Key facts

- **NCT ID:** NCT05639712
- **Lead sponsor:** Oslo University Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE4
- **Study type:** INTERVENTIONAL
- **Status:** COMPLETED
- **Start date:** 2022-12-13
- **Primary completion:** 2025-05-27
- **Final completion:** 2025-06-27
- **Target enrollment:** 1020 (ACTUAL)
- **Last updated:** 2025-09-04

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05639712

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05639712, "Affective Effects of Pre-surgery Opioids: a Randomized, Doubleblind Placebo-controlled Trial". Retrieved via AI Analytics 2026-06-25 from https://api.ai-analytics.org/clinical/NCT05639712. Licensed CC0.

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