# Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression

> **NCT05640336** · NA · ENROLLING_BY_INVITATION · sponsor: **Mayo Clinic** · enrollment: 490 (estimated)

## Conditions studied

- Periprosthetic Joint Infection

## Interventions

- **PROCEDURE:** Single Debridement, Antibiotics and Implant Retention
- **PROCEDURE:** Planned Double Debridement, Antibiotics and Implant Retention

## Key facts

- **NCT ID:** NCT05640336
- **Lead sponsor:** Mayo Clinic
- **Sponsor class:** OTHER
- **Phase:** NA
- **Study type:** INTERVENTIONAL
- **Status:** ENROLLING_BY_INVITATION
- **Start date:** 2023-03-03
- **Primary completion:** 2032-03
- **Final completion:** 2032-03
- **Target enrollment:** 490 (ESTIMATED)
- **Last updated:** 2025-12-18

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05640336

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05640336, "Treatment of Acute Periprosthetic Joint Infection Comparing Single and Planned Double-Debridement Antibiotics and Implant Retention Followed by Chronic Antibiotic Suppression". Retrieved via AI Analytics 2026-07-15 from https://api.ai-analytics.org/clinical/NCT05640336. Licensed CC0.

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