# Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders

> **NCT05656365** · — · RECRUITING · sponsor: **National Institute of Allergy and Infectious Diseases (NIAID)** · enrollment: 1500 (estimated)

## Conditions studied

- Periodic Fever, Aphthous Stomatitis, Pharyngitis, And Cervical Adenitis (Pfapa)
- Obstructive Sleep Apnea
- Tonsillitis
- Tonsil Disorder
- Sleep Disordered Breathing

## Interventions

_None listed._

## Key facts

- **NCT ID:** NCT05656365
- **Lead sponsor:** National Institute of Allergy and Infectious Diseases (NIAID)
- **Sponsor class:** NIH
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** RECRUITING
- **Start date:** 2023-05-23
- **Primary completion:** 2037-06-30
- **Final completion:** 2038-12-31
- **Target enrollment:** 1500 (ESTIMATED)
- **Last updated:** 2026-04-08


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05656365

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05656365, "Evaluating the Genetics and Immunology of Periodic Fever, Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis (PFAPA) Syndrome and Other Tonsil Disorders". Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/clinical/NCT05656365. Licensed CC0.

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