# RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors

> **NCT05660408** · PHASE1,PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **University of Florida** · enrollment: 36 (estimated)

## Conditions studied

- Recurrent Pulmonary Osteosarcoma
- Recurrent High-grade Glioma

## Interventions

- **BIOLOGICAL:** pp65 RNA LP (DP1)
- **BIOLOGICAL:** pp65/tumor mRNA RNA-LP (DP2)
- **PROCEDURE:** Surgical Biopsy/Resection

## Key facts

- **NCT ID:** NCT05660408
- **Lead sponsor:** University of Florida
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2025-03-12
- **Primary completion:** 2033-10
- **Final completion:** 2035-10
- **Target enrollment:** 36 (ESTIMATED)
- **Last updated:** 2026-03-09

## Collaborators

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## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05660408

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05660408, "RNA Lipid Particles Targeting Pediatric Recurrent Intracranial Malignancies and Other systEmic Solid Tumors". Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/clinical/NCT05660408. Licensed CC0.

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