# Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia

> **NCT05660473** · PHASE2 · RECRUITING · sponsor: **Institute of Hematology & Blood Diseases Hospital, China** · enrollment: 100 (estimated)

## Conditions studied

- Precursor Cell Lymphoblastic Leukemia-Lymphoma

## Interventions

- **DRUG:** Vincristine
- **DRUG:** Daunorubicin
- **DRUG:** Cyclophosphamide
- **DRUG:** Pegaspargase
- **DRUG:** Prednisone
- **DRUG:** Cytarabine
- **DRUG:** 6-mercaptopurine
- **DRUG:** Dexamethasone
- **DRUG:** Methotrexate
- **DRUG:** Venetoclax

## Key facts

- **NCT ID:** NCT05660473
- **Lead sponsor:** Institute of Hematology & Blood Diseases Hospital, China
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2022-08-01
- **Primary completion:** 2027-12-15
- **Final completion:** 2027-12-30
- **Target enrollment:** 100 (ESTIMATED)
- **Last updated:** 2025-08-01


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05660473

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05660473, "Pediatric-inspired Regimen Combined With Venetoclax for Adolescent and Adult Patients With de Novo Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia". Retrieved via AI Analytics 2026-06-05 from https://api.ai-analytics.org/clinical/NCT05660473. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*