# From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects

> **NCT05661903** · PHASE2 · RECRUITING · sponsor: **Massachusetts General Hospital** · enrollment: 180 (estimated)

## Conditions studied

- Chronic Pain

## Interventions

- **OTHER:** Spinal Cord Stimulator Set to Minimal/No Stimulation Setting
- **OTHER:** Usual Care
- **DRUG:** Positron Emission Tomography / Magnetic Resonance Imaging

## Key facts

- **NCT ID:** NCT05661903
- **Lead sponsor:** Massachusetts General Hospital
- **Sponsor class:** OTHER
- **Phase:** PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** RECRUITING
- **Start date:** 2023-06-08
- **Primary completion:** 2027-08-31
- **Final completion:** 2027-08-31
- **Target enrollment:** 180 (ESTIMATED)
- **Last updated:** 2025-06-27

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05661903

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05661903, "From Nerve to Brain: Toward a Mechanistic Understanding of Spinal Cord Stimulation in Human Subjects". Retrieved via AI Analytics 2026-06-09 from https://api.ai-analytics.org/clinical/NCT05661903. Licensed CC0.

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