# Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp

> **NCT05666089** · EARLY_PHASE1 · UNKNOWN · sponsor: **Cairo University** · enrollment: 30 (estimated)

## Conditions studied

- Intracanal Medication
- N-acetylcystine
- Calcium Hydroxide
- Mediators

## Interventions

- **DRUG:** N-acetyl cysteine
- **DRUG:** Calcium hydroxide

## Key facts

- **NCT ID:** NCT05666089
- **Lead sponsor:** Cairo University
- **Sponsor class:** OTHER
- **Phase:** EARLY_PHASE1
- **Study type:** INTERVENTIONAL
- **Status:** UNKNOWN
- **Start date:** 2023-02-01
- **Primary completion:** 2024-02-01
- **Final completion:** 2024-03-01
- **Target enrollment:** 30 (ESTIMATED)
- **Last updated:** 2022-12-27


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05666089

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05666089, "Effect of N-acetylcysteine Versus Calcium Hydroxide Used as an Intracanal Medicament on the Intensity of Postoperative Pain, Bacterial Load Reduction and Levels of MMP -9 in Periapical Fluids in Patients With Necrotic Pulp". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05666089. Licensed CC0.

---

*[Clinical trials dataset](/datasets/clinical-trials) · CC0 1.0*