# Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy

> **NCT05672316** · PHASE1,PHASE2 · ACTIVE_NOT_RECRUITING · sponsor: **City of Hope Medical Center** · enrollment: 28 (actual)

## Conditions studied

- Advanced Colorectal Adenocarcinoma
- Advanced Microsatellite Stable Colorectal Carcinoma
- Metastatic Colorectal Adenocarcinoma
- Metastatic Microsatellite Stable Colorectal Carcinoma
- Stage III Colorectal Cancer AJCC v8
- Stage IV Colorectal Cancer AJCC v8

## Interventions

- **BIOLOGICAL:** Balstilimab
- **PROCEDURE:** Biospecimen Collection
- **BIOLOGICAL:** Botensilimab
- **PROCEDURE:** Computed Tomography
- **DRUG:** Regorafenib

## Key facts

- **NCT ID:** NCT05672316
- **Lead sponsor:** City of Hope Medical Center
- **Sponsor class:** OTHER
- **Phase:** PHASE1,PHASE2
- **Study type:** INTERVENTIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2023-05-11
- **Primary completion:** 2025-05-10
- **Final completion:** 2026-08-25
- **Target enrollment:** 28 (ACTUAL)
- **Last updated:** 2026-01-28

## Collaborators

- [object Object]

## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05672316

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05672316, "Botensilimab, Balstilimab and Regorafenib for the Treatment of Patients With Microsatellite Stable Metastatic Colorectal Cancer Who Have Progressed on Prior Chemotherapy". Retrieved via AI Analytics 2026-07-27 from https://api.ai-analytics.org/clinical/NCT05672316. Licensed CC0.

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