# Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1

> **NCT05677594** · — · ACTIVE_NOT_RECRUITING · sponsor: **Johns Hopkins University** · enrollment: 80 (actual)

## Conditions studied

- Neurofibromatosis 1
- Malignant Peripheral Nerve Sheath Tumor (MPNST) of Soft Tissue (Diagnosis)
- Atypical Neurofibroma

## Interventions

- **DIAGNOSTIC_TEST:** Whole Body Magnetic Resonance Imaging

## Key facts

- **NCT ID:** NCT05677594
- **Lead sponsor:** Johns Hopkins University
- **Sponsor class:** OTHER
- **Phase:** —
- **Study type:** OBSERVATIONAL
- **Status:** ACTIVE_NOT_RECRUITING
- **Start date:** 2021-07-01
- **Primary completion:** 2028-06-30
- **Final completion:** 2028-06-30
- **Target enrollment:** 80 (ACTUAL)
- **Last updated:** 2026-01-12


## Primary source

ClinicalTrials.gov registry: https://clinicaltrials.gov/study/NCT05677594

## Citation

> US National Library of Medicine, ClinicalTrials.gov registration NCT05677594, "Multi-parametric Biomarker Development to Predict Malignant Conversion in Patients With Neurofibromatosis Type 1". Retrieved via AI Analytics 2026-06-02 from https://api.ai-analytics.org/clinical/NCT05677594. Licensed CC0.

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